Endocrine Abstracts

Background: Exposure to environmental radiation can cause stress and cumulative effect of such stress leads to DNA strand brake. Testicular function is particularly susceptible to radiation emitted by electromagnetic fields. Reports of declining male fertility have renewed interest in the role of environmental and occupational exposures in the aetiology of human infertility.Objectives: The aim of the present work was to investigate the effect of 10 GHz e...

The Indian Medical Practitioners Expressions Regarding Drug Interventions in All Aspects of Metabolic Syndrome (IMPERIAL) study-5 was planned to assess physicians’ perceptions regarding the relative importance and effectiveness of various methods used to upgrade or intensify insulin therapy in patients not achieving glycemic control.Seventy-four diabetologists/endocrinologists, with clinical experience of 20.25±5.0 years, attending a conference...

The patient now aged 28, was seen at the age of 8 years by an ophthalmologist when he fell down stairs and complained that he could not see from his right eye. He was confirmed to have optic disc hypoplasia in his right eye with acuity of 2/60. A CT scan of his head was reported normal. He was also short statured with his height being on 3rd centile. He was suspected to have partial growth hormone deficiency on the basis of insulin tolerance test and patient was placed on grow...

Preadipocytes differentiate into mature adipocytes when treated with insulin, T3, isobutylmethylxanthine and dexamethasone but the role of their autocrine factors in their survival and function has only recently been appreciated. We have examined the expression and role of autocrine FGF-2 during preadipocyte differentiation. Using human preadipocytes isolated from subcutaneous fat, we induced differentiation in differentiation medium with and without the insulin-sensitising dr...

Type 1 Diabetes is typically a disease of the young but can present at any age. It is important to ensure correct categorisation as the acute complications related to insulin deficiency can occur and can be life threatening. It is important for physicians to maintain a high index of suspicion while dealing with newly diagnosed diabetes in an older patient. The following case report illustrates the fact that Type 1 Diabetes can present in the elderly.CAS...

Introduction: The Syndrome of Inappropriate Antidiuretic Hormone (SIADH) is considered to be the most common cause of euvolemic hyponatremia. The most common malignancy associated with SIADH is small cell lung cancer with multiple myeloma only observed in few cases worldwide of SIADH. The first line of treatment used in multiple myeloma chemotherapy currently is a proteasome inhibitor, Bortezomib, which is considered significantly more tolerable compared with traditional chemo...

In the current era of multi-modal imaging being performed for various pathologies, incidental non-functioning pituitary microadenomas (NFPAs) are being increasingly identified. The available literature and guidance is limited on the long-term surveillance and monitoring and hence there is a wide variation in clinical practice across the UK. We conducted a retrospective study in our institution to compare the outcome in our cohort to the current literature.<p class="abstext...

Noradrenaline (NE) is a peripheral vasoconstrictor reducing mortality by 11% and major adverse events by two-thirds compared to dopamine [1]. NE acts as an agonist at alpha1 and beta1 receptors, with little-to-no beta2 or alpha2 activity. This vasoconstriction effect can be potent and can result in completely occluded blood vessels more frequently in the peripheries due to lower blood pressure. Septic shock accounts for nearly 1 in 10 admissions to ICU, where it is the most co...

• A 54-year old Lithuanian man presented with symptomatic hyperglycaemia and weight loss.• A diagnosis of new onset diabetes type 2 was confirmed for which he received treatment. In addition, his serum potassium remained low despite of intervention.• CXR was done and showed a bulky right sided hilar mass.• The combination of refractory hypokalaemia, hyperglycaemia, and lung cancer suspicio...

Objectives: Primary - Study of Correlation between Serum Osteoprotegerin, and Biomarkers of Bone Metabolism in Patients with treatment-naive Graves’ Disease (GD). Secondary- Serum level of Osteoprotegerin, TNF alfa and Biomarkers of Bone Metabolism in Patients 3 months after treatment of GD with methimazole (MMI).Material and Methods: A total of thirty-five treatment-naive newly diagnosed GD were recruited for the study, most of them were female. Al...